Stroke Treatments – Amazing New Research
Posted: Tuesday, May 04, 2010
by Dr. Ron Blankstein
Chesapeake Nutraceuticals
Prompt stroke treatments are vital since brain damage can begin within minutes. But new research may lead to therapies that restore brain and body function well after the stroke has occurred. It could open a whole new world of stroke treatments.
A stroke happens when a blood vessel in the brain gets blocked or bursts. Deprived of blood supply which carries oxygen the affected area of the brain starts to die. And the part of the body controlled by that area of the brain won't work right.
Warning Signs of a Stroke
Stroke is the third leading cause of death in the US, yet 40% of people cannot name even one of the warning signs of a stroke.(1) Just being familiar with stroke symptoms can make a huge difference in the outcome.
A stroke can cause:
- Blurred vision
- Drooling and trouble speaking
- Problems with balance and walking
- Severe headache different from any previous headache
- Inability to understand simple statements
- Sudden weakness or numbness on one side of the body, affecting face, arm or leg(2)
Stroke occurs in over 700,000 people per year in the United States that's one person every 45 seconds. Over the course of a lifetime, four out of five families are affected.(3)
The Future of Stroke Treatments
New studies have come out of the University of California that may improve and extend the scope of current stroke treatments. Presently, some treatments are only effective in the first few hours after a stroke has happened. And no drugs can help after several days.
But researcher Magda Guerra-Crespo has discovered that a small protein called transforming growth factor alpha (TGF alpha) can repair damage long after the stroke has occurred. TGF alpha has been studied in connection with other organs, but never with stroke and the brain until now.
Studies were conducted on rats, which exhibit stroke damage much like humans do by losing limb function on one side of the body.
Healthy rats, when put into a cylinder, will jump up with both front legs. Rats that have had a stroke will use just one leg, favoring their weak side. When walking, the injured rats will move toward their good side.
For the trial, rats were injected with TGF alpha about a month after having a stroke equal to about a year in humans. A month later they were hopping up in the cylinder with both legs and not favoring one side when walking. The TGF alpha rats regained 99% of lost movement compared to the untreated rats, who improved by only 30%.
Senior co-author of the study, James Fallon said, "Now we have evidence there may be therapies that can repair damage to a significant degree long after the stroke. It's a completely unexpected and remarkable finding, and it's worth trying in humans."(4)
Brain Regeneration
TGF alpha appears to stimulate neuron growth in the brain. It caused stem cells to divide, which then turned into brain cells. The new brain cells traveled to the injured part of the brain and replaced neurons the stroke had destroyed. Scientists believe that the new neurons helped restore motor function.
Graduate student Darius Gleason, who worked on the study, commented, "It's becoming more and more clear that the brain is like any other organ: It has a lot of potential to regenerate. We are just emulating nature by giving a little nudge to what the brain is trying to do itself."(5)
This is very promising news for future stroke treatments. Stroke is the leading cause of disability in the United States so long term methods of dealing with the after-effects will have a major impact on both the health of individuals and their return to productivity and normal life.
As always, before you make any changes to your diet, exercise or supplement routine, please check with your personal physician.
Sources:
- Vega J, "Interesting Facts and Statistics About Stroke," about.com, Nov 2, 2009
- Stroke Overview, WebMD.com
- Stroke Statistics, TheUniversityHospital.com, University Hospital, New Jersey
- Fitzenberger J, "New stroke therapy successful in rats: Protein completely restores motor function," University of California Irvine (2010 Jan 13
- Fitzenberger J, "New stroke therapy successful in rats: Protein completely restores motor function," University of California Irvine (2010 Jan 13
This Article has been viewed 285 times. (Not updated in real-time.)
No comments yet.We want your comments! If you can read this, you don't have javascript enabled, so you can't use this comment system. Please enable javascript.