A Cure for Type-1 Diabetes?
Posted: Saturday, February 13, 2010
by Dr. Ron Blankstein
Chesapeake Nutraceuticals
If you live with type-1 diabetes, you know the daily struggle. The daily insulin shots. The careful monitoring of the foods you eat. The blood sugar swings when you're not as careful as you should be.
Now imagine if you didn't need to have insulin shots or monitor your blood sugar levels. What would four years without worrying about your next insulin shot be like? For most people with type-1 diabetes, I'm sure the answer to that question is, "What a relief!"
Lay Down Your Burdens
Finding a way to replace your body's natural insulin production is the holy grail of type-1 diabetes research. Researchers are getting close to that goal.
Two different procedures are showing promise for diabetes patients. If either is perfected, you'll be able to replace the cells in your body that produce insulin. That means no more insulin shots.
Doctors have known for a while how to transplant insulin-producing beta cells. This technique works for a time, but eventually your body will attack and destroy those cells just like it did the original cells.
Because the cells come from an outside donor, the potential for rejection is also a problem. Most transplant patients rely on immune-suppressing drugs to prevent rejection. That leaves you vulnerable to illness and disease.
Stem Cells Carry New Hope for Diabetes Patients
With advances in stem cell research, the situation is changing. Doctors have been able to stimulate the growth of new beta cells within the pancreas by using a patient's own stem cells. This means your body won't reject the cells, and you won't have to take immune suppressants.
So far, only small studies have been done using this technique. But the results are promising. On average patients are able to function without insulin shots for 31 months. Some patients have enjoyed four years without insulin shots. Eighty-six percent of patients participating in this study responded well and were able to produce their own insulin, at least for a time.(1)
Doctors are also excited because the patients were able to maintain healthy blood sugar levels. "This was the first time in history we achieved normal blood sugar and A1c levels and were drug-free after one intervention," said Dr. Burt of the research team.(2)
This treatment doesn't eliminate the original autoimmune disorder that triggers type-1 diabetes, so eventually the body does attack the new beta cells. However because the cells come from your own stem cells, you could receive periodic treatments with low side effects and good results.
More Diabetes Relief
Researchers are also working on a way to protect transplanted beta cells from immune system attacks. They've found a way to wrap the cells in polytetrafluorethylene (PTFE). PTFE allows the cells to produce and release insulin while protecting them from a hostile immune system. In studies, this technique has worked very well. The new beta cells stabilized insulin production and glucose metabolism and the immune system ignored the new cells.(3)
I look forward to a day in the near future when these two procedures are combined to create a lasting, effective solution that will relieve patients of the daily burden of type-1 diabetes.
Remember, it's important to discuss changes to your diet, exercise, or supplements with your doctor.
- Couri CEB, et al. "C-Peptide Levels and Insulin Independence Following Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus," JAMA 2009; 301(15): 1573-79.
- Gardner, Amanda. "Stem Cells Buy Freedom From Insulin for Type 1 Diabetics," Drug Digest. 4/14/2009
- "Device Protects Transplanted Pancreatic Cells From The Immune System," Science Daily. 4/16/2009
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Top-level comments on this article: (1 total)LCT (living cell technologies) in New Zealand is in human trials with their product 'diabecell'...basically they have encapsulated pig islet cells is a sea-weed derived protective coating allowing the cells to function for many years without any immune response from the patient. so far trials have been very promising. trials are in new zealand, russia and soon to be in the united states.
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